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Pyjs

a Rich Internet Application (RIA) Development Platform for both Web and Desktop.

Pyjs is a port of Google Web Toolkit to Python, and thus enables the development of Rich Media AJAX applications in Python, with no need for special browser plugins. Pyjs contains a stand-alone python-to-javascript compiler, and also a Widget Set API that looks very similar to Desktop Widget Set APIs (such as PyQT4 or PyGTK2).

Pyjs also contains a Desktop Widget Set version, running as pure python, with three useable Desktop ports available. With web-engine technology at it's core, HTML, CSS, plugins and other related features work out-of-the-box.